Precision medicine (PM) aims to revolutionise healthcare, but little is known about the role religion and spirituality might play in the ethical discourse about PM. This Perspective reports the outcomes of a knowledge exchange fora with religious authorities in Singapore about data sharing for PM. While the exchange did not identify any foundational religious objections to PM, ethical concerns were raised about the possibility for private industry to profiteer from social resources and the potential for genetic discrimination by private health (...) insurers. According to religious authorities in Singapore, sharing PM data with private industry will require a clear public benefit and robust data governance that incorporates principles of transparency, accountability and oversight. (shrink)

Governments are investing in precision medicine with the aim of improving healthcare through the use of genomic analyses and data analytics to develop tailored treatment approaches for individual patients. The success of PM is contingent upon clear public communications that engender trust and secure the social licence to collect and share large population-wide data sets because specific consent for each data re-use is impractical. Variation in the terminology used by different programmes used to describe PM may hinder clear communication and (...) threaten trust. Language is used to create common understanding and expectations regarding precision medicine between researchers, clinicians and the volunteers. There is a need to better understand public interpretations of PM-related terminology. This paper reports on a qualitative study involving 24 focus group participants in the multi-lingual context of Singapore. The study explored how Singaporeans interpret and understand the terms ‘precision medicine’ and ‘personalised medicine’, and which term they felt more aptly communicates the concept and goals of PM. Results suggest that participants were unable to readily link the terms with this area of medicine and initially displayed preferences for the more familiar term of ‘personalised’. The use of visual aids to convey key concepts resonated with participants, some of whom then indicated preferences for the term ‘precision’ as being a more accurate description of PM research. These aids helped to facilitate dialogue around the ethical and social value, as well as the risks, of PM. Implications for programme developers and policy makers are discussed. (shrink)

Genetic information affects patients’ families differently than other types of medical information. Family members might have a compelling interest in patients’ genetic information, but who counts as family? In this article, I assess current definitions of family and propose a pluralistic account of family, which comprises definitions of family based on biomedical, legal, and functional aspects. Respectful of various forms of family, a pluralistic account includes those with interests in genetic information. Finally, I apply it in the hypothetical case of (...) a sperm donor with a hereditary condition. (shrink)

Background We aimed to examine the ethical concerns Singaporeans have about sharing health-data for precision medicine and identify suggestions for governance strategies. Just as Asian genomes are under-represented in PM, the views of Asian populations about the risks and benefits of data sharing are under-represented in prior attitudinal research. Methods We conducted seven focus groups with 62 participants in Singapore from May to July 2019. They were conducted in three languages and analysed with qualitative content and thematic analysis. Results Four (...) key themes emerged: nuanced understandings of data security and data sensitivity; trade-offs between data protection and research benefits; trust in the public and private sectors; and governance and control options. Participants were aware of the inherent risks associated with data sharing for research. Participants expressed conditional support for data sharing, including genomic sequence data and information contained within electronic medical records. This support included sharing data with researchers from universities and healthcare institutions, both in Singapore and overseas. Support was conditional on the perceived social value of the research and appropriate de-identification and data security processes. Participants suggested that a data sharing oversight body would help strengthen public trust and comfort in data research for PM in Singapore. Conclusion Maintenance of public trust in data security systems and governance regimes can enhance participation in PM and data sharing for research. Contrary to themes in much prior research, participants demonstrated a sophisticated understanding of the inherent risks of data sharing, analysed trade-offs between risks and potential benefits of PM, and often adopted an international perspective. (shrink)

Precision medicine is an emerging approach to treatment and disease prevention that relies on linkages between very large datasets of health information that is shared amongst researchers and health professionals. While studies suggest broad support for sharing precision medicine data with researchers at publicly funded institutions, there is reluctance to share health information with private industry for research and development. As the private sector is likely to play an important role in generating public benefits from precision medicine initiatives, it is (...) important to understand what the concerns are and how they might be mitigated. This study reports outcomes of a deliberative method of citizen engagement in Singapore that asked whether sharing precision medicine data with private industry would be permissible, and if so, under what circumstances. Findings from this citizens’ jury suggest sharing with industry would be permissible under certain conditions that are set out in nine recommendations. Implications of the recommendations and their underlying assumptions for policy decision makers are discussed. This study aligns with prior international studies which found conditional acceptance for data sharing with private industry, a public benefit requirement, specific reluctance to share with insurance companies and an emphasis on accountability and transparency to demonstrate trustworthiness. However, our results differ from prior studies in that opt-in consent did not dominate the deliberations as jurors were able to set it aside as an assumed prerequisite for participation in a precision medicine programme. (shrink)

Ontologies, as the term is used in informatics, are structured vocabularies comprised of human- and computer-interpretable terms and relations that represent entities and relationships. Within informatics fields, ontologies play an important role in knowledge and data standardization, representation, integra- tion, sharing and analysis. They have also become a foundation of artificial intelligence (AI) research. In what follows, we outline the Coronavirus Infectious Disease Ontology (CIDO), which covers multiple areas in the domain of coronavirus diseases, including etiology, transmission, epidemiology, pathogenesis, diagnosis, (...) prevention, and treatment. We emphasize CIDO development relevant to COVID-19. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Cải cách tiền lương là một trong những nội dung quan trọng sẽ được thảo luận tại Kỳ họp thứ 6, Quốc hội khóa XV và đây cũng là một trong những chìa khoá để mở ra các chính sách đãi ngộ nhằm góp phần xây dựng, phát triển đội ngũ trí thức nước nhà, đáp ứng yêu cầu phát triển đất nước nhanh và bền vững trong giai đoạn mới như nội dung mà Hội nghị Trung ương 8 khoá (...) XIII, Ban Chấp hành Trung ương Đảng đã thảo luận. (shrink)

It is often argued that oppression reduces freedom. I argue against the view that oppression is wrong because it reduces freedom. Conceiving oppression as wrong because it reduces freedom is at odds with recognizing structural cases of oppression, because (a) many cases of oppression, including many structural ones, do not reduce agents’ freedom, and (b) the type of freedom reduction involved in many structural instances of oppression is not morally objectionable. If the mechanisms of oppression are sometimes indistinguishable from benign, (...) or even ineluctable, processes of social shaping, arguments that oppression is objectionably freedom-reducing risk implausibly suggesting that socialization itself is objectionably freedom-reducing. I show how three strategies for explaining how oppression reduces freedom either fall into the trap of overgenerality, or end up appealing to values other than freedom to avoid it. I conclude by suggesting that oppression might be better thought of as an affront to equality. (shrink)

This paper provides examples drawn from the author’s experience that support the conclusion that errors and deceptions in archival science are often not easily or quickly corrected. The difficulty in correcting errors and deceptions needs wider recognition if it is to be overcome. In addition, the paper discusses how subtle abuses introduce errors into the archival literature.

Khader offers a deliberative perfectionist approach to identifying and responding to adaptive preferences-- deprived people's preferences that perpetuate their deprivation.

Decolonizing Universalism develops a genuinely anti-imperialist feminism. Against relativism/universalism debates that ask feminists to either reject normativity or reduce feminism to a Western conceit, Khader's nonideal universalism rediscovers the normative core of feminism in opposition to sexist oppression and reimagines the role of moral ideals in transnational feminist praxis.

This paper provides examples drawn from the author’s experience that support the conclusion that errors and deceptions in archival science are often not easily or quickly corrected. The difficulty in correcting errors and deceptions needs wider recognition if it is to be overcome. In addition, the paper discusses how subtle abuses introduce errors into the archival literature.

Feminist socially constitutive conceptions of autonomy make the presence of idealized social conditions necessary for autonomy. I argue that such conceptions cannot, when applied under nonideal conditions, play two key feminist theoretical roles for autonomy: the roles of anti-oppressive character ideal and paternalism-limiting concept. Instead, they prescribe action that reinforces oppression. Treated as character ideals, socially constitutive conceptions of autonomy ask agents living under nonideal ones to engage in self-harm or self-subordination. Moreover, conceptions of autonomy that make idealized social conditions (...) a requirement of autonomy yield the conclusion that oppressed agents are appropriate objects of paternalism. (shrink)

In times of pandemics or natural catastrophes, prices of commodities, such as water, food and medicines, tend to shoot up, in response to a surge in demand and depleting supplies. The government, in its misguided efforts to maintain “price affordability”, imposes price controls and anti-price-gouging legislation and bans the reselling of food and medical supplies. These interventions in the free market are the exact opposite of what the government should do, if it wants to ensure that enough commodities go to (...) people who need them, that people do not hoard all available goods on grocery shelves, and most importantly, that suppliers have the incentive to produce more goods to meet current and future demand at market prices. (shrink)

Biopolitics as a System of Thought takes seriously Foucault's claim that biopolitics is the primary technique of government, the means by which the organisation of our social relations operates. Engaging with modern political discussions such as black lives matter and Roe v Wade, Richards draws from jurists such as Pierre Legendre, Yan Thomas, and philosophers such as Agamben, Arendt, Esposito to explore how the same institutions that offer rights protection can easily and without much notice, take them away.

Critics argue that adaptive preference theorists misrepresent oppressed people's reasons for perpetuating their oppression. According to critics, AP theorists assume that people who adapt their preferences to unjust conditions lack the psychic capacities that would allow them to develop their own normative perspectives and/or form appropriate values. The misrepresentation is morally problematic, because it promotes unjustified paternalism and perpetuates colonial stereotypes of third‐world women. I argue that we can imagine a conception of AP that is consistent with acknowledging agency in (...) people who perpetuate their oppression. I offer a weak perfectionist conception of AP that is consistent with recognising agentic capacities in the oppressed. On my conception, APs are preferences incompatible with an agent's basic wellbeing that formed under unjust conditions — and that an agent would reverse upon exposure to better conditions. My conception encourages respectful treatment of the oppressed without requiring us to abandon the feminist political goals the notion of AP is meant to serve. It helps us identify real‐world preferences that are problematically adapted to oppressive conditions and offers an account of why they seem not to be women's ‘true preferences’. (shrink)

Introduction -- Direct algorithms of decompositions of matrices by non-orthogonal transformations -- Direct algorithms of decompositions of matrices by orthogonal transformations -- Direct algorithms of solution of linear equations -- Iterative algorithms of solution of linear equations -- Direct algorithms of solution of eigenvalue problem -- Iterative algorithms of solution of eigenvalue problem -- Algorithms of solution of singular value decomposition.

Cách mạng 4.0 đã và đang mang đến sự thay đổi lớn trong đời sống của người dân Việt Nam. Sự tiện dụng của Grab, khả năng cập nhật 24/24 của Facebook, hay sự đa dạng về nội dung của YouTube thúc đẩy xã hội tiến tới thời đại mới của khởi nghiệp điện toán (Vuong, 2019). Ở đó, mỗi cá nhân đều có cơ hội để khởi nghiệp thông qua sự kết nối đến khắp mọi nơi trên thế giới (...) của Internet và sức mạnh tính toán nằm gọn trong long bàn tay. Hiện nay, sản xuất video trên YouTube, cho thuê nhà qua AirBnb, hay chạy xe cho Grab tạo ra công việc có khả năng tạo lợi nhuận cho người tham gia thị trường, dù là người lao động, hay tổ chức cung ứng dịch vụ. (shrink)

Feminist, and other liberatory, moral and political philosophies are widely understood as nonideal theories. But if feminism is just a set of first-order normative commitments, it is unclear why it should produce action-guiding philosophy. I argue that feminist philosophy characteristically takes oppressive salience idealization (OSI) to undermine the means-end consistency of normative theories. OSI involves characterizing the world in ways that give undue weight to the interests and perspectives of the dominant. Our ability to respond to the normative problems our (...) actual world faces us with is undermined by OSI, especially at the levels of problem-framing and selection. (shrink)

This article provides information about Berne's financial situation at the time the Economic Society was founded. The canton was in an exceptionally fortunate position, having accumulated a sizeable cash reserve that was in part used for loans and investments on the London capital market. Throughout the century, the Bernese government followed a very cautious investment strategy. The main reason for purchasing overseas securities was that they helped the patricians to become independent from tax-paying subjects. Economic imperatives ruled out increases of (...) the cash reserve or further involvement in the overcrowded domestic capital market. However, by investing abroad Berne became increasingly dependent on the goodwill of its debtors, for which it was criticised by the Economic Patriots amongst others. (shrink)

This paper elaborates and renders explicit some of the views about political philosophical methodology that underlie the author’s arguments in Decolonizing Universalism: A Transnational Feminist Ethic. It shows how the author’s stances on autonomy, individualism, intersectionality, human rights, the coloniality of gender, and the oppression of genders besides man and woman grow out of a commitment to scrutinizing our normative views in light of transnational criticism and empirical information from the qualitative social sciences.

I argue that postcolonial feminist critiques draw our attention to four phenomena that are easily confused with what I call ?paradigmatic adaptive preference? ? and that the ability to distinguish these phenomena can improve the quality of development interventions. An individual has paradigmatic adaptive preferences (APs) if she perpetuates injustice against herself because her normative worldview is nearly completely distorted. The four look-alike phenomena postcolonial feminist critics help us identify are (a) APs caused by selective value distortion (SAPs), (b) APs (...) caused by forced tradeoffs (TAPs), (c) APs caused by misperceptions of the facts (MAPs), and (d) wellbeing-compatible preferences that are misunderstood because of a lack of cultural or contextual knowledge. The first three, I argue, are non-paradigmatic forms of AP that have gone previously unrecognized and that we need to expand our conceptual vocabulary to describe; the last is not a form of AP at all. Development practitioners can grapple more seriously with the real-world complexities of moral psychology and cross-cultural moral judgments if they are capable of distinguishing paradigmatic AP from the look-alike phenomena. (shrink)

ABSTRACT This symposium brings together commentaries on Serene J. Khader’s Decolonizing Universalism: A Transnational Feminist Ethic from Linda Martín Alcoff, Sunaina Arya, and Olúfẹ'mi O. Táíwò with a reply from Khader. Khader’s book aims to develop a conception of feminism that is both universalist and anti-imperialist. Central to this feminism are (a) the idea that the normative core of feminism is opposition to sexist oppression and (b) the idea that the role of normative concepts in transnational feminist praxis is (...) a justice-enhancing, or nonideal theoretical, one. Khader resists the universalism/relativism framing of debates in global feminisms and argues that opposition to sexist oppression can be detached from the values and social ontology of what she calls ‘Enlightenment liberalism’. She asks whether the values that are most often accused of being vehicles for Western imperialism, namely autonomy, individualism, and gender role eliminativism, are necessary for feminism at all. (shrink)

Photographic discourse between doxa and paradoxe appearing in 1839 as a technical process of representation of the image, in the amateur and enlightenment middle, Photography will produce a popular speech that will be exclusive for almost three decades: the photographic image is beautiful more perfect it is as an imitation of the reality. Clear and with formal information about time and space. This popular speech includes a short historical information about some authors of technical inventions that improved fixation and circulation (...) image. In the last quarter of that century, as a sensibleness against Industrial making, amateur photographs define an artistic and creative sight supported with a photographic theory, the Pictorialism, that overvalues the creative subject coinciding with new forms of Thought and Art. When Pictorialism is exhausted after the 1st G. War, a new sight which includes the ability of the new camera to mimic cinema effects, the subjective sight will no longer abandon the photographic practice while the photographic literature multiplies itself with the interest of philosophers, thinkers, film makers, psychologists and psychiatrists since the developing of the mass society. In the last quarter of the XX century, with post-modern inspiration, it appears as an international pattern a new History of Photography treated as History of Art, with styles and authors, that still remains. The objective of this work is to distinguish popular and scholarly photographic reading from its origins to the technological revolution that provokes a real crisis through the analysis of its greatest analysts. Taking into consideration our time, a period of numeric change, facing the new computational technology, that work with algoritms, image reading must change, but photographs and analysts repeat analog concept and strategies. (shrink)

I argue that the epistemological virtues of concrete thinking, self-transparency, and narrative understanding developed by care ethicists can help international development practitioners combat their own temptations to engage in “unconscious unjustified paternalism” (UUP). I develop the concept of UUP—a type of paternalism in which one party unjustifiably substitutes her judgment for another's because of difficulty distinguishing her desires for the other from the other's good. I show that the temptation to UUP is endemic to development and that care ethics contains (...) virtues for combating it. Key to my claim is a view of caregiving as a practice of negotiating conflict. (shrink)

Critics of transnational commercial surrogacy frequently call our attention to the race, class, and cultural background of surrogates in the global South. Consider the following sampling from the critics: "the women having babies for rich Westerners have been pimped by their husbands and are powerless to resist" (Bindel 2011); our "rules of decency seem to differ when the women in question are living in abject poverty half a world away" (Warner 2008); and we should worry that "women of color are (...) easier to commodify" (Smerdon 2008, 51-52). Critics suggest—rightly, in my view—that the race, class, and culture of Southern surrogates matter to the moral acceptability of transnational surrogacy. But how, precisely, do .. (shrink)

The “fathers’ rights” movement represents policies that undermine women's reproductive autonomy as furthering the cause of gender equality. Khader argues that this movement exploits two general weaknesses of equality claims identified by Luce Irigaray. She shows that Irigaray criticizes equality claims for their appeal to a genderneutral universal subject and for their acceptance of our existing symbolic repertoire. This article examines how the plaintiffs’ rhetoric in two contemporary “fathers’ rights” court cases takes advantage of these weaknesses.

Open Dialogue is an approach to working with mental health problems that emphasises promoting dialogue between multiple perspectives within an individual person and between all the people present, including the therapists. Therapists’ own perspectives are often introduced during conversations called reflections, which present a potential source of different perspectives. Using conversation analysis we analysed 14 hours of video-recorded Open Dialogue sessions with a focus on therapists’ reflections. We noticed that therapists did not display explicit agreement with each other’s reflections. This (...) absence of explicit agreement was displayed through a variety of verbal and non-verbal forms. Eliding agreement facilitated deference to the epistemic authority of the client, assertion of epistemic rights from second position, emphasis of a positive perspective or to voice multiple perspectives. Therapists avoided consensus and thus presented multiple perspectives to the family while also attending to issues of contingency. The implications of epistemic primacy and asymmetry connected to sequential structures in talk pose a challenge to the generation of collaborative reflective dialogues. (shrink)

This paper morally evaluates the phenomenon Sylvia Chant calls "the feminization of responsibility," wherein women's unrecognized labor subsidizes international development while men retain or increase their power over women. I argue that development policies that feminize responsibility are incompatible with justice in two ways. First, such policies involve Northerners extracting unpaid labor from women in the global South. Northerners are obligated to provide development assistance, but they are transferring the labor of providing it onto women in the global South and (...) expecting them to do it for free. Second, development policies that feminize responsibility increase women's exposure to sexist domination. These two problems are present irrespective of whether policies that feminize responsibility improve women's basic well-being. (shrink)

I argue that capabilities approaches are useful in formulating a political theory that takes seriously the needs of persons with severe cognitive disabilities (PSCD). I establish three adequacy criteria for theories of justice that take seriously the needs of PSCD: A) understanding PSCD as oppressed, B) positing a single standard of what is owed to PSCD abled individuals, and C) concern with flourishing as well as political liberty. I claim that conceiving valued capabilities as the end of social distribution may (...) help a political theory to meet these criteria.I posit three further adequacy criteria: D) refusing to see PSCD as less than human, E) valuing moral powers other than practical reason, and F) securing space for care and dependency relationships. I show that how well Elizabeth Anderson and Martha Nussbaum’s capabilities approaches meet these criteria depends on their divergent conceptions of what capabilities are for. I sketch another capabilities approach that might better meet the three latter criteria (inspired by Lawrence Becker and Eva Kittay’s work), that conceives capabilities as for agency and relationship. (shrink)

In a world where paid work is touted as a development panacea, empowering women has started to look a lot like burdening them. I argue here that this burdening of women is a predictable result of the conception of empowerment as choice or agency. Dominant conceptions of empowerment characterize empowerment as the increase in a person’s ability to do what they choose. Yet conditions of gender equality and poverty structure women’s options such that choosing, doing, and doing more are often (...) both women’s best option and modes of disempowerment. Seeing the way increased agency can be disempowering requires shifting away from the view that social structures disempower by constraining individual agency. We instead need a conception of power as a constraint on individual action to a conception of power as structuring the field of available actions in ways that affect the relative position of social groups. Through a discussion of the gender division of labor and the feminization of responsibility, I argue that a more feminist conception of empowerment will weaken the link between empowerment and individual agency. (shrink)

This paper discusses Diana Meyers's book in light of postcolonial feminist insights. It argues that though Meyers's defense of empathy is admirably sensitive to the ways philosophical concepts and popular discourses can undermine our empathetic capacities, building a human rights culture requires attention to the relational and distributional dimensions of empathy. Meyers's criticism of the expectation of moral purity from victims attests to the richness of her work on agency and helps dismantle unduly narrow conceptions of who counts as a (...) victim of a human rights violation. Meyers's argument for empathy over sympathy is especially useful for understanding culturally encoded forms of degradation. However, human rights violations are caused not only by empathy deficits; they are caused also by empathy excesses toward some people and savior mentalities that can coexist with empathy. Empathy should be supplemented by a political analysis that helps us identify the causes of global injustice. (shrink)

Although many scholars take parsimony for granted today, Elliott Sober shows in his latest book, Ockham’s Razors, that they might not be rationally justified to do so. In particular, he claims that the famous Ockham’s Razor, the heuristic that says one should not postulate more entities than necessary, rests on some implicit assumptions that go back to Newton and his rules of reasoning. The problem is that Newton justified those basic rules on theological grounds, that is, the world is parsimonious (...) because God is orderly. All is not lost : Sober suggests that two contemporary perspectives from probability theory do justify parsimony. The first one is related to Bayesianism, and the fact that Ockham’s Razor is embedded in Bayes’ theorem. Sober criticizes this view and argues for an alternative, one in which predictive accuracy is more fundamental. I suggest that Sober might be right about the unseen role of predictive accuracy, but that this does not entail that Bayesians should adhere to Sober’s framework. It is my contention that Sober’s case against Bayesian model selection has more to do with the Bayesian worldview than the methodology per se. (shrink)